Strain-Level Variation and Diverse Host Bacterial Responses in Episymbiotic Saccharibacteria

Author:

Nie Jie1,Utter Daniel R.2,Kerns Kristopher A.3,Lamont Eleanor I.3,Hendrickson Erik L.3,Liu Jett4,Wu Tingxi4,He Xuesong45,McLean Jeffrey3,Bor Batbileg45

Affiliation:

1. Department of Cariology and Endodontology, Peking University School of Stomatology, Beijing, China

2. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA

3. Department of Periodontics, University of Washington, Seattle, Washington, USA

4. The Forsyth Institute, Cambridge, Massachusetts, USA

5. Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA

Abstract

Candidate phylum radiation (CPR) bacteria comprise a poorly understood phylum that is estimated to encompass ∼26% of all diversity of domain bacteria. Among CPR bacteria, the Saccharibacteria lineage (TM7) is of particular interest, as it is found in high abundance in the mammal microbiome and has been associated with oral disease.

Funder

HHS | NIH | National Institute of Dental and Craniofacial Research

National Science Foundation

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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