Identification and Development of Therapeutics for COVID-19-Reference-Cited by-同舟云学术

Identification and Development of Therapeutics for COVID-19

Published:2021-12-21 Issue:6 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Rando Halie M.¹²³^ORCID,Wellhausen Nils¹^ORCID,Ghosh Soumita⁴^ORCID,Lee Alexandra J.¹^ORCID,Dattoli Anna Ada⁵^ORCID,Hu Fengling⁶^ORCID,Byrd James Brian⁷^ORCID,Rafizadeh Diane N.⁸⁹^ORCID,Lordan Ronan¹⁰^ORCID,Qi Yanjun¹¹^ORCID,Sun Yuchen¹¹,Brueffer Christian¹²^ORCID,Field Jeffrey M.⁵^ORCID,Ben Guebila Marouen¹³^ORCID,Jadavji Nafisa M.¹⁴¹⁵^ORCID,Skelly Ashwin N.⁸¹⁶^ORCID,Ramsundar Bharath¹⁷^ORCID,Wang Jinhui⁸^ORCID,Goel Rishi Raj¹⁶^ORCID,Park YoSon¹^ORCID,Boca Simina M.¹⁸¹⁹^ORCID,Gitter Anthony²⁰²¹^ORCID,Greene Casey S.²³⁵²²^ORCID,

Affiliation:

1. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA

3. Center for Health AI, University of Colorado School of Medicine, Aurora, Colorado, USA

4. Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

5. Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

6. Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA

7. University of Michigan School of Medicine, Ann Arbor, Michigan, USA

8. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

9. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA

10. Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

11. Department of Computer Science, University of Virginia, Charlottesville, Virginia, USA

12. Department of Clinical Sciences, Lund University, Lund, Sweden

13. Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA

14. Biomedical Science, Midwestern University, Glendale, Arizona, USA

15. Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada

16. Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

17. The DeepChem Project

18. Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA

19. Early Biometrics & Statistical Innovation, Data Science & Artificial Intelligence, R & D, AstraZeneca, Gaithersburg, Maryland, USA

20. Department of Biostatistics and Medical Informatics, University of Wisconsin—Madison, Madison, Wisconsin, USA

21. Morgridge Institute for Research, Madison, Wisconsin, USA

22. Childhood Cancer Data Lab, Alex’s Lemonade Stand Foundation, Philadelphia, Pennsylvania, USA

Abstract

The COVID-19 pandemic is a rapidly evolving crisis. With the worldwide scientific community shifting focus onto the SARS-CoV-2 virus and COVID-19, a large number of possible pharmaceutical approaches for treatment and prevention have been proposed.

Funder

American Heart Association

Fast Grants

Gordon and Betty Moore Foundation

HHS | National Institutes of Health

John W. and Jeanne M. Rowe Center for Research in Virology

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00233-21

Reference404 articles.

1. Rando HM MacLean AL Lee AJ Ray S Bansal V Skelly AN Sell E Dziak JJ Shinholster L McGowan LD … Greene CS. 2021. Pathogenesis symptomatology and transmission of SARS-CoV-2 through analysis of viral genomics and structure. arXiv https://arxiv.org/abs/2102.01521.

2. COVID-19 Review Consortium. 19 February 2021. SARS-CoV-2 and COVID-19: an evolving review of diagnostics and therapeutics. https://greenelab.github.io/covid19-review/v/d9d90fd7e88ef547fb4cbed0ef73baef5fee7fb5/%23vaccine-development-strategies-for-sars-cov-2.

3. A Visual Approach for the SARS (Severe Acute Respiratory Syndrome) Outbreak Data Analysis

4. Center for Systems Science and Engineering at Johns Hopkins University. COVID-19 Data Repository. GitHub https://github.com/CSSEGISandData/COVID-19/tree/master/csse_covid_19_data/csse_covid_19_time_series.

5. An interactive web-based dashboard to track COVID-19 in real time

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