Acinetobacter baumannii Targets Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAMs) for Invasion of Pneumocytes-Reference-Cited by-同舟云学术

Acinetobacter baumannii Targets Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAMs) for Invasion of Pneumocytes

Published:2020-12-22 Issue:6 Volume:5 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Ambrosi Cecilia¹^ORCID,Scribano Daniela²³,Sarshar Meysam⁴⁵⁶,Zagaglia Carlo²,Singer Bernhard B.⁷,Palamara Anna Teresa¹⁴

Affiliation:

1. IRCCS San Raffaele Pisana, Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy

2. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy

3. Dani Di Giò Foundation-Onlus, Rome, Italy

4. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Laboratory affiliated to Institute Pasteur Italia-Cenci Bolognetti Foundation, Rome, Italy

5. Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran

6. Research Laboratories, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

7. Institute of Anatomy, Medical Faculty, University Duisburg-Essen, Essen, Germany

Abstract

This work shows for the first time that Acinetobacter baumannii binds to carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM5, and CEACAM6. This binding significantly enhances A. baumannii internalization within alveolar host cell epithelia.

Funder

Ministero della Difesa

Dani DiGio Foundation

Deutsche Forschungsgemeinschaft

Ministero della Salute

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00604-20

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