Effects of ‘Healthy’ Fecal Microbiota Transplantation against the Deterioration of Depression in Fawn-Hooded Rats

Author:

Hu Bing12,Das Promi3,Lv Xianglin1,Shi Meng4,Aa Jiye5,Wang Kun6,Duan Liping6,Gilbert Jack A.3,Nie Yong1,Wu Xiao-Lei17ORCID

Affiliation:

1. College of Engineering, Beijing University, Beijing, People’s Republic of China

2. Institute of Biochemical Engineering, College of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, People’s Republic of China

3. Department of Pediatrics and Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA

4. Beijing University Hospital of Stomatology, Beijing, People’s Republic of China

5. Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, People’s Republic of China

6. Beijing University Third Hospital, Beijing, People’s Republic of China

7. Institute of Ecology, Beijing University, Beijing, People’s Republic of China

Abstract

Depression is a chronic, recurrent mental disease, which could make the patients commit suicide in severe cases. Considering that gut microbiome dysbiosis could cause depressive symptoms in animals through the MGB axis, the modification of gut microbiota is expected to be a potential therapy for depression, but the daily administration of probiotics is invalid or transient.

Funder

National Natural Science Foundation of China

CAS | State Key Laboratory of Biochemical Engineering

Ministry of Science and Technology of the People's Republic of China

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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