Alterations in Gut Glutamate Metabolism Associated with Changes in Gut Microbiota Composition in Children with Autism Spectrum Disorder

Author:

Wang Mingbang1ORCID,Wan Jing2,Rong Han3,He Fusheng4,Wang Hui5,Zhou Jiaxiu6,Cai Chunquan7,Wang Yan4,Xu Ruihuan8,Yin Zhaoqing2,Zhou Wenhao1

Affiliation:

1. Shanghai Key Laboratory of Birth Defects, Division of Neonatology, Children’s Hospital of Fudan University, National Center for Children’s Health, Shanghai, China

2. Division of Neonatology, The People’s Hospital of Dehong Autonomous Prefecture, Mangshi, Yunnan, China

3. Shenzhen Key Laboratory for Psychological Healthcare, Shenzhen Institute of Mental Health, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, China

4. Imunobio, Shenzhen, Guangdong, China

5. Xiamen branch of Children’s Hospital of Fudan University (Xiamen Children’s Hospital), Xiamen, Fujian, China

6. Division of Psychology, Shenzhen Children’s Hospital, Shenzhen, Guangdong, China

7. Division of Neurosurgery, Tianjin Children’s Hospital, Tianjin, China

8. Clinical Laboratory, Longgang Central Hospital of Shenzhen, Guangdong, China

Abstract

Multiple lines of evidence suggest that the gut microbiota may play an important role in the pathogenesis of ASD, but the specific mechanism is still unclear. Through a comprehensive gut metagenomic and metabolome study of children with ASD, alterations in gut metabolite composition were found in children with ASD, and these alterations were linked to changes in gut microbiota composition. This may give us a deeper understanding of the role of gut microbiota in the pathogenesis of ASD.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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