A Previously Undescribed Highly Prevalent Phage Identified in a Danish Enteric Virome Catalog

Author:

Van Espen Lore1ORCID,Bak Emilie Glad2,Beller Leen1,Close Lila1,Deboutte Ward1ORCID,Juel Helene Bæk2,Nielsen Trine2,Sinar Deniz1,De Coninck Lander1,Frithioff-Bøjsøe Christine23,Fonvig Cilius Esmann23,Jacobsen Suganya45,Kjærgaard Maria45,Thiele Maja45,Fullam Anthony6,Kuhn Michael6,Holm Jens-Christian237,Bork Peer68910,Krag Aleksander45,Hansen Torben2,Arumugam Manimozhiyan2ORCID,Matthijnssens Jelle1ORCID

Affiliation:

1. KU Leuven, Department of Microbiology, Immunology, & Transplantation, Rega Institute, Division of Clinical & Epidemiological Virology, Laboratory of Viral Metagenomics, Leuven, Belgium

2. The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

3. The Children’s Obesity Clinic, accredited European Centre for Obesity Management, Department of Paediatrics, Copenhagen University Hospital Holbaek, Holbaek, Denmark

4. Department of Gastroenterology and Hepatology, Centre for Liver Research, Odense University Hospital, Odense, Denmark

5. Department of Clinical Research, University of Southern Denmark, Odense, Denmark

6. Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany

7. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

8. Max Delbrück Centre for Molecular Medicine, Berlin, Germany

9. Yonsei Frontier Lab (YFL), Yonsei University, Seoul, South Korea

10. Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany

Abstract

Through generation of the DEVoC, we added numerous previously uncharacterized viral genomes and genes to the ever-increasing worldwide pool of human gut viromes. The DEVoC, the largest human gut virome catalog generated from consistently processed fecal samples, facilitated the analysis of the 91 healthy Danish gut viromes.

Funder

Novo Nordisk Foundation

Innovation Fund Denmark

Region Zealand Health Scientific Research Foundation

European Union's Horizon2020

Fonds Wetenschappelijk Onderzoek

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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