Nutrient Availability and Phage Exposure Alter the Quorum-Sensing and CRISPR-Cas-Controlled Population Dynamics of Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Nutrient Availability and Phage Exposure Alter the Quorum-Sensing and CRISPR-Cas-Controlled Population Dynamics of Pseudomonas aeruginosa

Published:2022-08-30 Issue:4 Volume:7 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Ahator Stephen Dela¹²^ORCID,Sagar Sadhanna¹³,Zhu Minya¹³,Wang Jianhe¹³,Zhang Lian-Hui¹³^ORCID

Affiliation:

1. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China

2. Centre for New Antibacterial Strategies (CANS) & Research Group for Host-Microbe Interactions, Faculty of Health Sciences, The Arctic University of Norway, Tromsø, Norway

3. Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China

Abstract

The increase in antimicrobial resistance has created the need for alternative interventions such as phage therapy. However, as previously observed with antimicrobial resistance, phage therapy will not be effective if bacteria evolve resistance and persist in the presence of the phages.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.00092-22

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