Leveraging Immunopeptidomics To Study and Combat Infectious Disease-Reference-Cited by-同舟云学术

Leveraging Immunopeptidomics To Study and Combat Infectious Disease

Published:2021-08-31 Issue:4 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Leddy Owen K.¹²³,White Forest M.¹²⁴,Bryson Bryan D.¹³^ORCID

Affiliation:

1. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

2. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

3. Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA

4. Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

Abstract

T cells must recognize pathogen-derived peptides bound to major histocompatibility complexes (MHCs) in order to initiate a cell-mediated immune response against an infection, or to support the development of high-affinity antibody responses. Identifying antigens presented on MHCs by infected cells and professional antigen-presenting cells (APCs) during infection may therefore provide a route toward developing new vaccines.

Funder

MIT Department of Biological Engineering

HHS | NIH | National Cancer Institute

HHS | National Institutes of Health

Ragon Institute of MGH, MIT and Harvard

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00310-21

Reference94 articles.

1. T-cell–B-cell cooperation

2. Pathways of Antigen Processing

3. The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules

4. HLA variation and disease

5. Characterization of Peptides Bound to the Class I MHC Molecule HLA-A2.1 by Mass Spectrometry

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