The Extracellular Milieu of Toxoplasma 's Lytic Cycle Drives Lab Adaptation, Primarily by Transcriptional Reprogramming-Reference-Cited by-同舟云学术

The Extracellular Milieu of Toxoplasma 's Lytic Cycle Drives Lab Adaptation, Primarily by Transcriptional Reprogramming

Published:2021-12-21 Issue:6 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Primo Vincent A.¹,Rezvani Yasaman²,Farrell Andrew³,Murphy Connor Q.¹,Lou Jingjing¹,Vajdi Amir⁴,Marth Gabor T.³,Zarringhalam Kourosh²,Gubbels Marc-Jan¹^ORCID

Affiliation:

1. Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA

2. Department of Mathematics, University of Massachusetts Boston, Boston, Massachusetts, USA

3. Department of Human Genetics and USTAR Center for Genetic Discovery, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA

4. Department of Computer Science, University of Massachusetts Boston, Boston, Massachusetts, USA

Abstract

It has been well established that prolonged in vitro cultivation of Toxoplasma gondii augments progression of the lytic cycle. This lab adaptation results in increased capacities to divide, migrate, and survive outside a host cell, all of which are considered host-independent virulence factors.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.01196-21

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