Transcriptional Profiling Reveals the Importance of RcrR in the Regulation of Multiple Sugar Transportation and Biofilm Formation in Streptococcus mutans

Author:

Gong Tao1,He Xiaoya1,Chen Jiamin12,Tang Boyu12,Zheng Ting1,Jing Meiling12,Lin Yongwang12,Pan Yangyang13,Ma Qizhao13,Li Yuqing1ORCID,Zhou Xuedong12

Affiliation:

1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China

2. Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China

3. Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China

Abstract

The human oral cavity is a constantly changing environment. Tooth decay is a commonly prevalent chronic disease mainly caused by the cariogenic bacterium Streptococcus mutans . S. mutans is an oral pathogen that metabolizes various carbohydrates into extracellular polysaccharides (EPSs), biofilm, and tooth-destroying lactic acid.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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