Quantitative Proteomics Reveals that Hsp90 Inhibition Dynamically Regulates Global Protein Synthesis in Leishmania mexicana-Reference-Cited by-同舟云学术

Quantitative Proteomics Reveals that Hsp90 Inhibition Dynamically Regulates Global Protein Synthesis in Leishmania mexicana

Published:2021-06-29 Issue:3 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Kalesh Karunakaran¹^ORCID,Sundriyal Sandeep²,Perera Hirunika¹,Cobb Steven L.¹,Denny Paul W.³

Affiliation:

1. Department of Chemistry, Durham University, Durham, United Kingdom

2. Department of Pharmacy, Birla Institute of Technology and Science, Pilani, India

3. Department of Biosciences, Durham University, Durham, United Kingdom

Abstract

Leishmania spp. are the causative agents of leishmaniasis, a poverty-related disease, which is endemic in >90 countries worldwide, affecting approximately 12 million people, with an estimated 700,000 to 1 million new cases and around 70,000 deaths annually. Inhibitors of the chaperone protein Hsp90 have shown promising antileishmanial activity.

Funder

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00089-21

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