High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response-Reference-Cited by-同舟云学术

High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response

Published:2022-04-26 Issue:2 Volume:7 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Ng Tai L.¹²,Olson Erika J.¹²,Yoo Tae Yeon¹,Weiss H. Sloane¹²,Koide Yukiye¹²,Koch Peter D.¹²,Rollins Nathan J.¹,Mach Pia¹²,Meisinger Tobias¹,Bricken Trenton¹,Chang Timothy Z.¹²,Molloy Colin¹²,Zürcher Jérôme¹,Chang Roger L.¹²,Mitchison Timothy J.¹,Glass John I.³,Marks Debora S.¹,Way Jeffrey C.¹²⁴,Silver Pamela A.¹²⁴

Affiliation:

1. Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA

2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA

3. J. Craig Venter Institute, La Jolla, California, USA

4. Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

Abstract

Infectious diseases caused by viral pathogens exacerbate health care and economic burdens. Numerous viral biomolecules suppress the human innate immune system, enabling viruses to evade an immune response from the host.

Funder

HHS | National Institutes of Health

ODNI | Intelligence Advanced Research Projects Activity

Open Philanthropy Project

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.01466-21

Reference41 articles.

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2. Intracellular sensing of viral genomes and viral evasion

3. Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections

4. Viruses and interferon: a fight for supremacy

5. Viral tricks to grid-lock the type I interferon system

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