Phylogenetic Analysis and Virulence Characteristics of Methicillin-Resistant Staphylococcus aureus ST45 in China: a Hyper-Virulent Clone Associated with Bloodstream Infections-Reference-Cited by-同舟云学术

Phylogenetic Analysis and Virulence Characteristics of Methicillin-Resistant Staphylococcus aureus ST45 in China: a Hyper-Virulent Clone Associated with Bloodstream Infections

Published:2023-04-27 Issue:2 Volume:8 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Wang Xinyi¹,Wu Xiaocui¹,Shen Li¹,Rao Lulin¹,Wang Bingjie¹,Zhao Huilin¹,Zhang Jiao¹,Xiao Yanghua¹,Guo Yinjuan¹,Xu Yanlei¹,Chen Liang²³^ORCID,Yu Fangyou¹^ORCID

Affiliation:

1. Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China

2. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

3. Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA

Abstract

Methicillin-resistant Staphylococcus aureus ST45 is epidemic worldwide. This study contributed to the awareness of the Chinese hyper-virulent MRSA ST45 strains and served as a timely reminder of its wide dissemination of clonotypes. Further, we provide novel insights for prevention from the perspective of bloodstream infections. ST45-SCC mec V is a clonotype deserving special attention in China, and we performed genetic and phenotypic analyses for the first time on it.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.00029-23

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