Candida Administration Worsens Uremia-Induced Gut Leakage in Bilateral Nephrectomy Mice, an Impact of Gut Fungi and Organismal Molecules in Uremia-Reference-Cited by-同舟云学术

Candida Administration Worsens Uremia-Induced Gut Leakage in Bilateral Nephrectomy Mice, an Impact of Gut Fungi and Organismal Molecules in Uremia

Published:2021-02-23 Issue:1 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Panpetch Wimonrat¹,Kullapanich Chitrasak²³,Dang Cong Phi⁴,Visitchanakun Peerapat⁴,Saisorn Wilasinee⁴,Wongphoom Jutamas⁵,Wannigama Dhammika Leshan¹⁶⁷,Thim-uam Arthid⁸,Patarakul Kanitha¹,Somboonna Naraporn²³,Tumwasorn Somying¹,Leelahavanichkul Asada¹⁹

Affiliation:

1. Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

2. Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand

3. Microbiome Research Unit for Probiotics in Food and Cosmetics, Chulalongkorn University, Bangkok, Thailand

4. Medical Microbiology, Interdisciplinary Program, Graduate School, Chulalongkorn University, Bangkok, Thailand

5. Department of Pathology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand

6. School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Nedlands, Western Australia, Australia

7. Antimicrobial Resistance and Stewardship Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

8. Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, Thailand

9. Translational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Chulalongkorn University, Bangkok, Thailand

Abstract

The impact of fungi in the intestine on acute uremia was demonstrated by the oral administration of Candida albicans in mice with the removal of both kidneys. Because fungi in the mouse intestine are less abundant than in humans, a Candida -administered mouse model has more resemblance to patient conditions.

Funder

Rachadapisek Sompote Fund for Postdoctoral Fellowship, Chulalongkorn University

Chulalongkorn University

Faculty of Medicine, Chulalongkorn University

Thailand Science Research and Innovation

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.01187-20

Reference79 articles.

1. Acute Kidney Injury and Mortality in Hospitalized Patients

2. Immune Dysfunction in Uremia—An Update

3. Circulating Endotoxemia: A Novel Factor in Systemic Inflammation and Cardiovascular Disease in Chronic Kidney Disease

4. Endotoxemia in Chronic Renal Failure

5. Surface area of the digestive tract – revisited

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