Genomic Diversity of Hospital-Acquired Infections Revealed through Prospective Whole-Genome Sequencing-Based Surveillance-Reference-Cited by-同舟云学术

Genomic Diversity of Hospital-Acquired Infections Revealed through Prospective Whole-Genome Sequencing-Based Surveillance

Published:2022-06-28 Issue:3 Volume:7 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Mustapha Mustapha M.¹²,Srinivasa Vatsala R.¹²,Griffith Marissa P.¹²,Cho Shu-Ting¹,Evans Daniel R.¹,Waggle Kady¹²,Ezeonwuka Chinelo¹²,Snyder Daniel J.³,Marsh Jane W.¹²,Harrison Lee H.¹²,Cooper Vaughn S.³⁴^ORCID,Van Tyne Daria¹⁴^ORCID

Affiliation:

1. Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

2. Microbial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

3. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pennsylvania, USA

4. Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA

Abstract

Hospitalized patients are at increased risk of becoming infected with antibiotic-resistant organisms. We used whole-genome sequencing to survey and compare over 3,000 clinical bacterial isolates collected from hospitalized patients at a large medical center over a 2-year period.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Advancing Translational Sciences

University of Pittsburgh Department of Medicine

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.01384-21

Reference67 articles.

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3. Centers for Disease Control and Prevention. 2020. Dec 02. Current HAI progress report. https://www.cdc.gov/hai/data/portal/progress-report.html. Accessed 05/05/2021.

4. Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

5. Centers for Disease Control and Prevention. 2013. ANTIBIOTIC RESISTANCE THREATS in the United States, 2013. CDC.

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