Vascular Proteome Responses Precede Organ Dysfunction in a Murine Model of Staphylococcus aureus Bacteremia

Author:

Sorrentino James T.12,Golden Gregory J.34,Morris Claire34,Painter Chelsea D.34,Nizet Victor56,Campos Alexandre Rosa7,Smith Jeffrey W.7,Karlsson Christofer8,Malmström Johan8,Lewis Nathan E.259,Esko Jeffrey D.34,Gómez Toledo Alejandro8

Affiliation:

1. Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California, USA

2. Department of Bioengineering, University of California, San Diego, La Jolla, California, USA

3. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA

4. Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA

5. Department of Pediatrics, University of California, San Diego, La Jolla, California, USA

6. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA

7. The Cancer Center and The Inflammatory and Infectious Disease Center, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California, USA

8. Department of Clinical Sciences, Division of Infection Medicine, Lund University, BMC, Lund, Sweden

9. National Biologics Facility, Technical University of Denmark, Krogens-Lyngby, Denmark

Abstract

Sepsis is a life-threatening response to infection that results in immune dysregulation, vascular dysfunction, and organ failure. New methods are needed for the identification of diagnostic and therapeutic targets.

Funder

Novo Nordisk Fonden

HHS | NIH | National Institute of General Medical Sciences

NIH grant

Wallenberg Foundation

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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