A Novel Synbiotic Alleviates Autoimmune Hepatitis by Modulating the Gut Microbiota-Liver Axis and Inhibiting the Hepatic TLR4/NF-κB/NLRP3 Signaling Pathway-Reference-Cited by-同舟云学术

A Novel Synbiotic Alleviates Autoimmune Hepatitis by Modulating the Gut Microbiota-Liver Axis and Inhibiting the Hepatic TLR4/NF-κB/NLRP3 Signaling Pathway

Published:2023-04-27 Issue:2 Volume:8 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Kang Yongbo¹,Kuang Xiaoyu¹,Yan Huan¹,Ren Peng¹,Yang Xiaodan¹,Liu Haixia¹,Liu Qingqing¹,Yang Hao¹,Kang Xing¹,Shen Xiaorong¹,Tong Mingwei¹,Li Lin¹,Wang Xiaohui²,Guo Linzhi²,Ma Jieqiong¹,Zhang Fan¹,Fan Weiping¹

Affiliation:

1. Department of Microbiology and Immunology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, China

2. Laboratory of Morphology, Shanxi Medical University, Taiyuan, Shanxi, China

Abstract

Synbiotics can ameliorate liver injury and improve liver function by reducing hepatic inflammation and pyroptosis. Our data indicate that our new Syn not only reverses gut dysbiosis by increasing beneficial bacteria and decreasing lipopolysaccharide (LPS)-bearing Gram-negative bacteria but also maintains intestinal barrier integrity.

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.01127-22

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