Unique Features of the Gut Microbiome Characterized in Animal Models of Angelman Syndrome-Reference-Cited by-同舟云学术

Unique Features of the Gut Microbiome Characterized in Animal Models of Angelman Syndrome

Published:2023-02-23 Issue:1 Volume:8 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Beitnere Ulrika¹²,Vilanova-Cuevas Brayan³,Christian Sarah G.⁴,Taylor Clint⁴,Berg Elizabeth L.⁵,Copping Nycole A.⁵,Dindot Scott V.⁴,Silverman Jill L.⁵,Gareau Mélanie G.³^ORCID,Segal David J.¹²

Affiliation:

1. Genome Center, University of California Davis, Davis, California, USA

2. Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA

3. Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA

4. Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, USA

5. Department of Psychiatry and Behavioral Sciences, University of California Davis, Davis, California, USA

Abstract

Angelman syndrome (AS)-associated gastrointestinal (GI) symptoms significantly impact quality of life in patients. In AS models in mouse, rat, and pig, AS animals showed impaired colonization of the gut microbiota compared to wild-type (healthy) control animals. Common changes in AS microbiomes across all three animal models may play a causal effect for GI symptoms and may help to identify ways to treat these comorbidities in patients in the future.

Funder

Foundation for Angelman Syndrome Therapeutics

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute of Mental Health

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.00608-22

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