Elucidating the Diversity and Potential Function of Nonribosomal Peptide and Polyketide Biosynthetic Gene Clusters in the Root Microbiome-Reference-Cited by-同舟云学术

Elucidating the Diversity and Potential Function of Nonribosomal Peptide and Polyketide Biosynthetic Gene Clusters in the Root Microbiome

Published:2020-12-22 Issue:6 Volume:5 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Dror Barak¹²,Wang Zongqiang³,Brady Sean F.³,Jurkevitch Edouard²,Cytryn Eddie¹^ORCID

Affiliation:

1. Institute of Soil, Water and Environmental Sciences, Agricultural Research Organization, Rishon-Lezion, Israel

2. Department of Plant Pathology and Microbiology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel

3. Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, New York, USA

Abstract

We identified distinct secondary-metabolite-encoding genes that are enriched (relative to adjacent bulk soil) and expressed in root ecosystems yet almost completely absent in human gut and aquatic environments. Several of the genes were distantly related to genes encoding antimicrobials and siderophores, and their high sequence variability relative to known sequences suggests that they may encode novel metabolites and may have unique ecological functions.

Funder

United States - Israel Binational Agricultural Research and Development Fund

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00866-20

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