Identification of a GrgA-Euo-HrcA Transcriptional Regulatory Network in Chlamydia-Reference-Cited by-同舟云学术

Identification of a GrgA-Euo-HrcA Transcriptional Regulatory Network in Chlamydia

Published:2021-08-31 Issue:4 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Wurihan Wurihan¹^ORCID,Zou Yi²,Weber Alec M.¹,Weldon Korri²,Huang Yehong¹³^ORCID,Bao Xiaofeng⁴,Zhu Chengsheng⁵,Wu Xiang³,Wang Yaqun⁶,Lai Zhao²⁷,Fan Huizhou¹^ORCID

Affiliation:

1. Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA

2. Greehey Children’s Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, USA

3. Department of Parasitology, Central South University Xiangya Medical School, Changsha, Hunan, China

4. Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, China

5. Department of Microbiology and Biochemistry, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, USA

6. Department of Biostatistics, School of Public Health, Rutgers University, New Brunswick, New Jersey, USA

7. Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas, USA

Abstract

Chlamydia trachomatis is the most prevalent sexually transmitted bacterial pathogen worldwide and is a leading cause of preventable blindness in underdeveloped areas as well as some developed countries. Chlamydia carries genes that encode a limited number of known transcription factors. While Euo is thought to be critical for early chlamydial development, the functions of GrgA and HrcA in the developmental cycle are unclear.

Funder

HHS | NIH | NIH Office of the Director

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

New Jersey Health Foundation

China Scholarship Council

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00738-21

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