The Effect of <i>Limosilactobacillus reuteri</i> on Social Behavior Is Independent of the Adaptive Immune System-Reference-Cited by-同舟云学术

The Effect of Limosilactobacillus reuteri on Social Behavior Is Independent of the Adaptive Immune System

Published:2022-12-20 Issue:6 Volume:7 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Dooling Sean W.¹²³,Sgritta Martina¹²,Wang I-Ching¹²,Duque Ana Luiza Rocha Faria⁴,Costa-Mattioli Mauro¹²³

Affiliation:

1. Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA

2. Memory and Brain Research Center, Baylor College of Medicine, Houston, Texas, USA

3. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA

4. Department of Food and Nutrition, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Brazil

Abstract

Because preclinical animal studies support the idea that gut microbes could represent novel therapeutics for brain disorders, it is essential to fully understand the mechanisms by which gut microbes affect their host’s physiology. Previously, we discovered that treatment with Limosilactobacillus reuteri selectively improves social behavior in different mouse models for autism spectrum disorder through the vagus nerve, oxytocin reward signaling in the brain, and biopterin metabolites (BH4) in the gut.

Funder

HHS | National Institutes of Health

Sammons Enterprise

Simons Foundation Autism Research Initiative

Sao Paulo Research Foundation

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.00358-22

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