Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes-Reference-Cited by-同舟云学术

Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes

Published:2021-06-29 Issue:3 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Jeon Jehyun¹,Lee Jaehee²,Jung Se-Min²,Shin Jae Hong¹,Song Woon Ju²^ORCID,Rho Mina¹³^ORCID

Affiliation:

1. Department of Computer Science, Hanyang University, Seoul, Republic of Korea

2. Department of Chemistry, Seoul National University, Seoul, Republic of Korea

3. Department of Biomedical Informatics, Hanyang University, Seoul, Republic of Korea

Abstract

Halogenases are playing an important role as tailoring enzymes in biosynthetic pathways. Flavin-dependent tryptophan halogenases (Trp-FDHs) are among the enzymes that have broad substrate scope and high selectivity.

Funder

Ministry of Oceans and Fisheries

National Research Foundation of Korea

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00053-21

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5. Halogen bonding in halocarbon–protein complexes: a structural survey

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