Natural Green Spaces, Sensitization to Allergens, and the Role of Gut Microbiota during Infancy

Author:

Buchholz Vienna1,Bridgman Sarah L.1,Nielsen Charlene C.1,Gascon Mireia234,Tun Hein M.56,Simons Elinor7,Turvey Stuart E.8,Subbarao Padmaja9,Takaro Tim K.10,Brook Jeffrey R.11,Scott James A.11,Mandhane Piush J.1,Kozyrskyj Anita L.1

Affiliation:

1. Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

2. Barcelona Institute for Global Health (ISGlobal), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain

3. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

4. Universitat Pompeu Fabra (UPF), Barcelona, Spain

5. The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China

6. Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China

7. Section of Allergy & Immunology, Department of Pediatrics & Child Health, University of Manitoba and Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada

8. Department of Pediatrics, BC Children’s Hospital, The University of British Columbia, Vancouver, British Columbia, Canada

9. Department of Pediatrics and Physiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

10. Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada

11. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

Abstract

Our findings highlight the importance of preserving natural green space in urban settings to prevent sensitization to environmental allergens and promote early-life gut microbiota pathways to this health benefit. These findings support a mediating role of gut microbiome compositions in health and disease susceptibility.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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