Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice-Reference-Cited by-同舟云学术

Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice

Published:2022-06-28 Issue:3 Volume:7 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Fang Heng¹²³,Wang Yirong³,Deng Jia¹⁴,Zhang Huidan²³,Wu Qingrui³,He Linling³,Xu Jing¹³,Shao Xin³,Ouyang Xin³,He Zhimei³,Zhou Qiuping³,Wang Huifang³,Deng Yiyu¹²,Chen Chunbo¹²³⁵^ORCID

Affiliation:

1. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China

2. Department of Critical Care Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China

3. Department of Intensive Care Unit of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China

4. Department of Critical Care Medicine, The Second Hospital of Dalian Medical University, Dalian, China

5. Clinical Research Center, Maoming People’s Hospital, Maoming, Guangdong, China

Abstract

The bidirectional interactions between the gut microbiota and sepsis-associated encephalopathy (SAE) are not well characterized. We found that the gut microbiota was more severely disturbed in SAE-susceptible (SES) mice than in SAE-resistant (SER) mice after sepsis modeling.

Funder

Science and Technology Program of Guangzhou City

Maoming Science and Technology Project

Guangdong Province High-level Hospital Construction Project of Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciencesl

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.01399-21

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