Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A-Reference-Cited by-同舟云学术

Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A

Published:2021-06-29 Issue:3 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Del Carratore Francesco¹^ORCID,Iorio Marianna²,Pérez-Bonilla Mercedes³,Schmidt Kamila¹,Pérez-Redondo Rosario⁴,Sosio Margherita²,Macdonald Sandy J.⁵,Gyulev Ivan S.⁵,Tsigkinopoulou Areti¹⁶,Thomas Gavin H.⁵,Genilloud Olga³,Rodríguez-García Antonio⁴,Donadio Stefano²,Breitling Rainer¹,Takano Eriko¹^ORCID

Affiliation:

1. Manchester Institute of Biotechnology, Faculty of Science and Engineering, University of Manchester, Manchester, United Kingdom

2. NAICONS Srl, Milan, Italy

3. Fundación MEDINA, Parque Tecnológico Ciencias de la Salud, Granada, Spain

4. INBIOTEC Instituto de Biotecnología de León, León, Spain

5. Department of Biology, University of York, Heslington, York, United Kingdom

6. DTU Biosustain, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark

Abstract

Planobispora rosea is a genetically intractable bacterium used for the production of GE2270A on an industrial scale. GE2270A is a potent thiopeptide antibiotic currently used as a precursor for the synthesis of two compounds under clinical studies for the treatment of Clostridium difficile infection and acne.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

H2020 Industrial Leadership

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00341-21

Reference61 articles.

1. Antibiotic GE2270 A: A novel inhibitor of bacterial protein synthesis. I. Isolation and characterization.

2. Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu

3. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

4. Heterologous Expression of the Thiopeptide Antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor Requires Deletion of Ribosomal Genes from the Expression Construct

5. Capturing Linear Intermediates and C-Terminal Variants during Maturation of the Thiopeptide GE2270

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