Dietary Fiber Ameliorates Lipopolysaccharide-Induced Intestinal Barrier Function Damage in Piglets by Modulation of Intestinal Microbiome

Author:

Sun Xiao1,Cui Yalei123,Su Yingying1,Gao Zimin1,Diao Xinying1,Li Ju4,Zhu Xiaoyan123,Li Defeng123,Li Zhentian123,Wang Chengzhang123,Shi Yinghua123ORCID

Affiliation:

1. College of Animal Science and Technology, Henan Agricultural University, Zhengzhou, China

2. Henan Key Laboratory of Innovation and Utilization of Grassland Resources, Zhengzhou, China

3. Henan Forage Engineering Technology Research Center, Zhengzhou, China

4. Henan Yinfa Animal Husbandry Co., Xinzheng, China

Abstract

Adding DF to the diet of LPS-challenged piglets alleviated intestinal and systemic inflammation, improved intestinal barrier function, and ultimately alleviated the growth retardation of piglets. In addition, the addition of DF significantly increased the relative abundance of SCFA-producing bacteria and the production of SCFAs.

Funder

Science and Technology Research Key Project of Education Department of Henan Province

Opening Project of National Engineering Laboratory for Wheat & Corn Further Processing of Henan University of Technology

Earmarked Fund for Modern Agro-industry Technology Research System

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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