Longitudinal Evaluation of Gut Bacteriomes and Viromes after Fecal Microbiota Transplantation for Eradication of Carbapenem-Resistant Enterobacteriaceae

Author:

Liu Qin1234ORCID,Zuo Tao1234,Lu Wenqi1234,Yeoh Yun Kit15,Su Qi1234,Xu Zhilu1234,Tang Whitney1234,Yang Keli12,Zhang Fen1234,Lau Louis H. S.2,Lui Rashid N. S.2,Chin Miu Ling5,Wong Rity2,Cheung Chun Pan1234,Zhu Wenyi1234,Chan Paul K. S.15ORCID,Chan Francis K. L.1234,Lui Grace C.2,Ng Siew C.1234

Affiliation:

1. Center for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong, China

2. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China

3. Microbiota I-Center, Hong Kong, China

4. Institute of Digestive Disease, State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China

5. Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, China

Abstract

Fecal microbiota transplantation (FMT) is an effective treatment for multidrug-resistant organisms; however, introducing a complex mixture of microbes also has unknown consequences for landscape features of gut microbiome. We sought to understand bacteriome and virome alterations in patients undergoing FMT to treat infection with carbapenem-resistant Enterobacteriaceae .

Funder

Chinese University of Hong Kong

Hong Kong Special Administrative Region Government

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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