Genomic Stability and Genetic Defense Systems in Dolosigranulum pigrum , a Candidate Beneficial Bacterium from the Human Microbiome

Author:

Flores Ramos Stephany1ORCID,Brugger Silvio D.123ORCID,Escapa Isabel Fernandez134ORCID,Skeete Chelsey A.1,Cotton Sean L.1,Eslami Sara M.1,Gao Wei13,Bomar Lindsey13,Tran Tommy H.4,Jones Dakota S.5,Minot Samuel5,Roberts Richard J.6,Johnston Christopher D.135ORCID,Lemon Katherine P.1478ORCID

Affiliation:

1. The Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA

2. Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

3. Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA

4. Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

5. Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

6. New England Biolabs, Ipswich, Massachusetts, USA

7. Division of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

8. Section of Infectious Diseases, Texas Children’s Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA

Abstract

Dolosigranulum pigrum is a candidate beneficial bacterium with potential for future therapeutic use. This is based on its positive associations with characteristics of health in multiple studies of human nasal microbiota across the span of human life.

Funder

The Forsyth Institute

Swiss National Science Foundation and Swiss Foundation for Grants in Biology and Medicine

HHS | NIH | National Institute of Dental and Craniofacial Research

HHS | NIH | National Institute of General Medical Sciences

Novartis Stiftung für Medizinisch-Biologische Forschung

Promedica Stiftung

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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