Evolution of Ciprofloxacin Resistance-Encoding Genetic Elements in Salmonella

Author:

Chen Kaichao1,Yang Chen1,Dong Ning1,Xie Miaomiao1,Ye Lianwei1,Chan Edward Wai Chi2,Chen Sheng1ORCID

Affiliation:

1. Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong

2. State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, China

Abstract

Resistance of nontyphoidal Salmonella to fluoroquinolones such as ciprofloxacin is known to be mediated by target mutations. This study surveyed the prevalence of Salmonella strains recovered from 2,989 food products in Shenzhen, China, during the period 2012 to 2017 and characterized the genetic features of several PMQR gene-bearing plasmids and ciprofloxacin resistance-encoding DNA fragments.

Funder

National Key Research and Development Plan

Basic Research Fund of Shenzhen City

Collaborative Research Fund of Hong Kong Research Grant Council

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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