Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria Is Governed by Global Transcriptional Regulator NagR-Reference-Cited by-同舟云学术

Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria Is Governed by Global Transcriptional Regulator NagR

Published:2022-10-26 Issue:5 Volume:7 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Arzamasov Aleksandr A.¹^ORCID,Nakajima Aruto²,Sakanaka Mikiyasu²^ORCID,Ojima Miriam N.²,Katayama Takane²,Rodionov Dmitry A.¹,Osterman Andrei L.¹

Affiliation:

1. Infectious and Inflammatory Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA

2. Graduate School of Biostudies, Kyoto University, Kyoto, Japan

Abstract

The predominance of bifidobacteria in the gut of breastfed infants is attributed to the ability of these bacteria to metabolize human milk oligosaccharides (HMOs). Thus, individual HMOs such as lacto- N -tetraose (LNT) and lacto- N -neotetraose (LNnT) are considered promising prebiotics that would stimulate the growth of bifidobacteria and confer multiple health benefits to preterm and malnourished children suffering from impaired (stunted) gut microbiota development.

Funder

HHS | National Institutes of Health

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.00343-22

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