<i>Staphylococcus aureus</i>Infection Initiates Hypoxia-Mediated Transforming Growth Factor-β1 Upregulation to Trigger Osteomyelitis-Reference-Cited by-同舟云学术

Staphylococcus aureusInfection Initiates Hypoxia-Mediated Transforming Growth Factor-β1 Upregulation to Trigger Osteomyelitis

Published:2022-08-30 Issue:4 Volume:7 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Zhang Wei¹,Lin Yiwei¹,Zong Yang¹,Ma Xin¹,Jiang Chaolai¹,Shan Haojie¹,Xia Wenyang¹,Yin Lifu¹,Wang Nan²,Zhou Lihui³,Zhou Zubin¹,Yu Xiaowei¹

Affiliation:

1. Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

2. Department of Emergency, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

3. Department of Orthopaedic Surgery, Xiangshan First People’s Hospital, Ningbo, Zhejiang, China

Abstract

The pathogenesis of osteomyelitis induced byStaphylococcus aureusremains unclear. To develop therapeutic approaches for osteomyelitis, it is important to understand the molecular mechanisms of its pathogenesis. Our results suggests that hypoxia/HIF-1α/TGF-β1 signaling is involved in osteomyelitis pathogenesis. Thus, these findings highlight the potential of this signaling components as therapeutic targets for the treatment of osteomyelitis.

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.00380-22

Reference32 articles.

1. Osteomyelitis

2. Interaction of staphylococci with bone

3. Future Clinical and Economic Impact of Revision Total Hip and Knee Arthroplasty

4. Community-Associated MRSA — Resistance and Virulence Converge

5. The microbiology of chronic osteomyelitis: Prevalence of resistance to common empirical anti-microbial regimens

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