Antibody Levels to Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLγ11 and DBLδ-1 Predict Reduction in Parasite Density-Reference-Cited by-同舟云学术

Antibody Levels to Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLγ11 and DBLδ-1 Predict Reduction in Parasite Density

Published:2021-06-29 Issue:3 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Araj Brittany N.¹,Swihart Bruce²,Morrison Robert³,Gonzales Hurtado Patricia¹,Teo Andrew³,Mahamar Almahamoudou⁴,Attaher Oumar⁴,Diarra Bacary S.⁴,Gaoussou Santara⁴,Issiaka Djibrilla⁴,Dicko Alassane⁴,Duffy Patrick E.³,Fried Michal¹^ORCID

Affiliation:

1. Molecular and Pathogenesis Biomarkers Section, Laboratory of Malaria Immunology and Vaccinology (LMIV), National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA

2. Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, NIH, Rockville, Maryland, USA

3. Pathogenesis and Immunity Section, Laboratory of Malaria Immunology and Vaccinology (LMIV), National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA

4. Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Dentistry, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali

Abstract

Plasmodium infection causes devastating disease and high mortality in young children. Immunity develops progressively as children acquire protection against severe disease, although reinfections and recrudescences still occur throughout life in areas of endemicity, partly due to parasite immunoevasion via switching of variant proteins such as Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed on the infected erythrocyte surface.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00347-21

Reference41 articles.

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