Metabolic Modeling and Bidirectional Culturing of Two Gut Microbes Reveal Cross-Feeding Interactions and Protective Effects on Intestinal Cells-Reference-Cited by-同舟云学术

Metabolic Modeling and Bidirectional Culturing of Two Gut Microbes Reveal Cross-Feeding Interactions and Protective Effects on Intestinal Cells

Published:2022-10-26 Issue:5 Volume:7 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Hirmas Belén¹,Gasaly Naschla²³,Orellana Guillermo¹,Vega-Sagardía Marco¹,Saa Pedro¹⁴,Gotteland Martín³,Garrido Daniel¹^ORCID

Affiliation:

1. Department of Chemical and Bioprocess Engineering, School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

2. Laboratory of Innate Immunity, Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile

3. Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile

4. Institute for Mathematical and Computational Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

Abstract

Microbial interactions represent the inner connections in the gut microbiome. By integrating mathematical modeling tools and microbial bidirectional culturing, we determined how two gut commensals engage in the exchange of cross-feeding metabolites, lactate and succinate, for increased growth in two fibers.

Funder

Agencia Nacional de Investigación y Desarrollo

Seed Fund PUC

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.00646-22

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