A High-Content Microscopy Screening Identifies New Genes Involved in Cell Width Control in Bacillus subtilis

Author:

Juillot Dimitri1,Cornilleau Charlène1,Deboosere Nathalie23,Billaudeau Cyrille1,Evouna-Mengue Parfait4,Lejard Véronique4,Brodin Priscille23,Carballido-López Rut1,Chastanet Arnaud1ORCID

Affiliation:

1. Micalis Institute, INRAE, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France

2. University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, CIIL-Center for Infection and Immunity of Lille, U1019-UMR 9017, Lille, France

3. University of Lille, CNRS, INSERM, US41-UMS2014-PLBS, Lille, France

4. Université Paris-Saclay, INRAE, MetaGenoPolis, Jouy-en-Josas, France

Abstract

Bacterial shape is primarily dictated by the external cell wall, a vital structure that, as such, is the target of countless antibiotics. Our understanding of how bacteria synthesize and maintain this structure is therefore a cardinal question for both basic and applied research.

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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