Comparative Genomics Reveals a Remarkable Biosynthetic Potential of the Streptomyces Phylogenetic Lineage Associated with Rugose-Ornamented Spores-Reference-Cited by-同舟云学术

Comparative Genomics Reveals a Remarkable Biosynthetic Potential of the Streptomyces Phylogenetic Lineage Associated with Rugose-Ornamented Spores

Published:2021-08-31 Issue:4 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Chung Yoon-Hee¹,Kim Hiyoung¹,Ji Chang-Hun¹,Je Hyun-Woo¹,Lee Dongho²,Shim Sang Hee³,Joo Hwang-Soo⁴,Kang Hahk-Soo¹^ORCID

Affiliation:

1. Department of Biomedical Science and Engineering, Konkuk University, Seoul, South Korea

2. Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea

3. Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, South Korea

4. College of Science and Technology, Duksung Women’s University, Seoul, South Korea

Abstract

It is now well recognized that members of the genus Streptomyces still harbor a large number of cryptic BGCs in their genomes, which are mostly silent under laboratory culture conditions. Activation of transcriptionally silent BGCs is technically challenging and thus forms a bottleneck when taking a gene-first approach for the discovery of new natural products.

Funder

National Research Foundation of Korea

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00489-21

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