Affiliation:
1. Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 and
2. Department of Pathology, Case Western Reserve University, Cleveland, Ohio 441062
Abstract
ABSTRACT
Agar dilution was used to test the activities of HMR 3647, erythromycin A, azithromycin, clarithromycin, roxithromycin, clindamycin, and quinupristin-dalfopristin against 235 strains of
Enterococcus faecalis
. HMR 3647 was the most active compound (MICs at which 50 and 90% of the isolates are inhibited [MIC
50
and MIC
90
, respectively] of 0.06 and 4.0 μg/ml, respectively). The MIC
50
and MIC
90
(with the MIC
50
given first and the MIC
90
given second; both in micrograms per milliliter) for other compounds were as follows: 4.0 and >32.0 for erythromycin A, 16.0 and >32.0 for azithromycin, 2.0 and >32 for clarithromycin, 32.0 and >32.0 for roxithromycin, 32.0 and >32.0 for clindamycin, and 8.0 and 16.0 for quinupristin-dalfopristin. All compounds were only bacteriostatic.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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