Oral Bioavailability and Pharmacokinetics of Trovafloxacin in Patients with AIDS-Reference-Cited by-同舟云学术

Oral Bioavailability and Pharmacokinetics of Trovafloxacin in Patients with AIDS

Published:1999-12 Issue:12 Volume:43 Page:3005-3007
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lacy Melinda K.¹,Nicolau David P.²³,Nightingale Charles H.²⁴,Geffken Amy⁵,Teng Renli⁵,Vincent John⁵,Quintiliani Richard⁴

Affiliation:

1. Department of Pharmacy Practice, University of Kansas Medical Center, Kansas City, Kansas 661601;

2. Department of Pharmacy Research,2

3. Division of Infectious Diseases,3 Hartford Hospital, Hartford, Connecticut 06102; and

4. Office for Research Administration,4 and

5. Pfizer Central Research, Groton, Connecticut 063405

Abstract

ABSTRACT Trovafloxacin pharmacokinetics were evaluated in 12 subjects with AIDS. By using a randomized design, single 200-mg doses of oral trovafloxacin and intravenous alatrofloxacin were administered. The mean absolute bioavailability was 91%. The pharmacokinetics of trovafloxacin when administered orally as the active form or intravenously as the prodrug (alatrofloxacin) are not altered in subjects with AIDS compared to those in healthy adults.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.12.3005

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