Differential Requirements for T Cells in Viruslike Particle- and Rotavirus-Induced Protective Immunity-Reference-Cited by-同舟云学术

Differential Requirements for T Cells in Viruslike Particle- and Rotavirus-Induced Protective Immunity

Published:2008-03-15 Issue:6 Volume:82 Page:3135-3138
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Blutt Sarah E.¹²,Warfield Kelly L.¹,Estes Mary K.¹,Conner Margaret E.¹²

Affiliation:

1. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030F

2. Michael E. Debakey Veterans Affairs Medical Center, Houston, Texas 77030

Abstract

ABSTRACT Correlates of protection from rotavirus infection are controversial. We compared the roles of B and T lymphocytes in protective immunity induced either by intranasally administered nonreplicating viruslike particles or inactivated virus or by orally administered murine rotavirus. We found that protection induced by nonreplicating vaccines requires CD4 + T cells and CD40/CD40L. In contrast, T cells were not required for short-term protective immunity induced by infection, but both T-cell-dependent and -independent mechanisms contributed to long-term maintenance of protection. Our findings indicate that more than one marker of protective immunity exists and that these markers depend on the vaccine that is administered.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01727-07

Reference24 articles.

1. Bertolotti-Ciarlet, A., M. Ciarlet, S. E. Crawford, M. E. Conner, and M. K. Estes. 2003. Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice. Vaccine21:3885-3900.

2. Blutt, S. E., K. L. Warfield, D. E. Lewis, and M. E. Conner. 2002. Early response to rotavirus infection involves massive B cell activation. J. Immunol.168:5716-5721.

3. Blutt, S. E., K. L. Warfield, C. M. O'Neal, M. K. Estes, and M. E. Conner. 2006. Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs). Vaccine24:1170-1179.

4. Casola, A., M. K. Estes, S. E. Crawford, P. L. Ogra, P. B. Ernst, R. P. Garofalo, and S. E. Crowe. 1998. Rotavirus infection of cultured intestinal epithelial cells induces secretion of CXC and CC chemokines. Gastroenterology114:947-955.

5. Antibody-Independent Protection against Rotavirus Infection of Mice Stimulated by Intranasal Immunization with Chimeric VP4 or VP6 Protein

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