Synergistic activity of azithromycin and gamma interferon in murine toxoplasmosis-Reference-Cited by-同舟云学术

Synergistic activity of azithromycin and gamma interferon in murine toxoplasmosis

Published:1991-08 Issue:8 Volume:35 Page:1672-1673
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Araujo F G¹,Remington J S¹

Affiliation:

1. Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, Palo Alto, California 94301.

Abstract

A dose of 75 mg of azithromycin per kg of body weight per day combined with a dose of 2 micrograms of gamma interferon per day and administered for 10 days protected at least 40% of mice infected with a lethal inoculum of Toxoplasma gondii. Azithromycin administered alone protected less than 10% of the mice; gamma interferon had no protective effect.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.35.8.1672

Reference8 articles.

1. Toxoplasmosis in immunocompromised patients;Araujo F. G.;Eur. J. Clin. Microbiol. Infect. Dis.,1987

2. Araujo F. G. R. M. Shepard and J. S. Remington. In vivo activity of the antibiotics macrolides azithromycin roxithromycin and spiramycin against Toxoplasma gondii. Eur. J. Clin. Microbiol. Infect. Dis. in press.

3. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome;Gordin F. M.;Ann. Intern. Med.,1984

4. Toxoplasmic encephalitis in patients with AIDS;Israelski D. M.;Infect. Dis. Clin. N. Am.,1988

5. Activity of gamma interferon in combination with pyrimethamine of clindamycin in treatment of murine toxoplasmosis;Israelski D. M.;Eur. J. Clin. Microbiol. Infect. Dis.,1990

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