The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking De Novo Formation of the Membranous Replication Compartment-Reference-Cited by-同舟云学术

The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking De Novo Formation of the Membranous Replication Compartment

Published:2021-10-27 Issue:22 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Riva Laura¹,Goellner Sarah²³⁴,Biering Scott B.⁵,Huang Chun-Teng¹,Rubanov Andrey N.¹,Haselmann Uta²⁴,Warnes Colin M.⁵,De Jesus Paul D.¹,Martin-Sancho Laura¹,Terskikh Alexey V.¹,Harris Eva⁵,Pinkerton Anthony B.¹,Bartenschlager Ralf²³⁴^ORCID,Chanda Sumit K.¹^ORCID

Affiliation:

1. Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA

2. Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany

3. Division of Virus-Associated Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany

4. German Center for Infection Research (DZIF), Heidelberg Partner Site, Heidelberg, Germany

5. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, USA

Abstract

This study describes the elucidation of (2E)-N-benzyl-3-(4-butoxyphenyl)prop-2-enamide (SBI-0090799) as a selective and potent inhibitor of Zika virus (ZIKV) replication using a high-throughput screening approach. Mapping and resistance studies, supported by electron microscopy observations, indicate that the small molecule is functioning through inhibition of NS4A-mediated formation of ZIKV replication compartments in the endoplasmic reticulum (ER).

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00996-21

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