N-Linked Glycans Shape Skin Immune Responses during Arthritis and Myositis after Intradermal Infection with Ross River Virus

Author:

Tharmarajah Kothila123,Everest-Dass Arun4,Vider Jelena2,Liu Xiang123,Freitas Joseph R.123,Mostafavi Helen123,Bettadapura Jayaram123,von Itzstein Mark4ORCID,West Nicholas P.2,Taylor Adam123ORCID,Mahalingam Suresh123ORCID,Zaid Ali123ORCID

Affiliation:

1. Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

2. School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, Queensland, Australia

3. Global Virus Network (GVN) Centre for Excellence in Arboviruses, Griffith University, Gold Coast, Queensland, Australia

4. Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia

Abstract

Arthritogenic alphaviruses are transmitted via mosquito bites through the skin, potentially causing debilitating diseases. Our understanding of how viral infection starts in the skin and how virus systemically disseminates to cause disease remains limited.

Funder

Department of Health | National Health and Medical Research Council

Menzies Health Institute Queensland

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference69 articles.

1. Arboviruses: A global public health threat

2. Arthritogenic alphaviruses: epidemiological and clinical perspective on emerging arboviruses

3. Rheumatic manifestations of chikungunya: emerging concepts and interventions

4. The Pathogenesis of Alphaviruses

5. Schmaljohn AL, McClain D. 1996. Alphaviruses (Togaviridae) and flaviviruses (Flaviviridae). In Baron S (ed), Medical microbiology [internet] 4th ed. University of Texas Medical Branch at Galveston, Galveston, TX. http://www.ncbi.nlm.nih.gov/books/NBK7633/

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