WTAP Targets the METTL3 m <sup>6</sup> A-Methyltransferase Complex to Cytoplasmic Hepatitis C Virus RNA to Regulate Infection-Reference-Cited by-同舟云学术

WTAP Targets the METTL3 m ⁶ A-Methyltransferase Complex to Cytoplasmic Hepatitis C Virus RNA to Regulate Infection

Published:2022-11-23 Issue:22 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sacco Matthew T.¹,Bland Katherine M.¹,Horner Stacy M.¹²^ORCID

Affiliation:

1. Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, North Carolina, USA

2. Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA

Abstract

Positive-strand RNA viruses such as HCV represent a significant global health burden. Previous work has described that HCV RNA contains the RNA modification m 6 A and how this modification regulates viral infection.

Funder

HHS | NIH | National Cancer Institute

Burroughs Wellcome Fund

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00997-22

Reference66 articles.

1. Hepatitis C virus infection

2. Replication of hepatitis C virus

3. Spatiotemporal Analysis of Hepatitis C Virus Infection

4. Signals Involved in Regulation of Hepatitis C Virus RNA Genome Translation and Replication

5. N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

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