Evaluation of Ciprofloxacin and Levofloxacin Disk Diffusion and Etest Using the 2019 Enterobacteriaceae CLSI Breakpoints

Author:

Humphries Romney M.12,Hindler Janet A.3,Shaffer Keith4,Campeau Shelley A.1

Affiliation:

1. Accelerate Diagnostics, Tucson, Arizona, USA

2. University of Arizona, Department of Pathology, Tucson, Arizona, USA

3. Los Angeles Department of Public Health, Los Angeles, California, USA

4. UCLA Clinical Microbiology Department, Los Angeles, California, USA

Abstract

In 2019, the Clinical and Laboratory Standards Institute (CLSI) published revisions to the Enterobacteriaceae ciprofloxacin and levofloxacin breakpoints. We evaluated the performance of disk diffusion and Etest compared to that of reference broth microdilution by use of the revised breakpoints.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference8 articles.

1. Chantell C, Humphries RM, Lewis JII. 2019. Ciprofloxacin, and levofloxacin Enterobacteriaceae and Pseudomonas aeruginosa rationale document, in press. Clinical and Laboratory Standards Institute, Wayne, PA.

2. Clinical and Laboratory Standards Institute. 2018. Performance standards for antimicrobial disk susceptibility tests. M02 standard, 13th ed. Clinical and Laboratory Standards Institute, Wayne, PA.

3. Clinical and Laboratory Standards Institute. 2018. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. M07 standard, 11th ed. Clinical and Laboratory Standards Institute, Wayne, PA.

4. Clinical and Laboratory Standards Institute. 2018. Performance standards for antimicrobial susceptibility testing. M100 standard, 28th ed. Clinical and Laboratory Standards Institute, Wayne, PA.

5. Clinical and Laboratory Standards Institute. 2018. Development of in vitro susceptibility testing criteria and quality control parameters. M23 guideline, 4th ed. Clinical and Laboratory Standards Institute, Wayne, PA.

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