Novel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors-Reference-Cited by-同舟云学术

Novel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors

Published:2019-06 Issue:6 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Berube Bryan J.¹,Russell Dara¹,Castro Lina¹,Choi Seoung-ryoung²³,Narayanasamy Prabagaran²³,Parish Tanya¹

Affiliation:

1. TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA

2. Department of Pathology, University of Nebraska Medical Center, Omaha, Nebraska, USA

3. Department of Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA

Abstract

Mycobacterium tuberculosis is the leading cause of morbidity and death resulting from infectious disease worldwide. The incredible disease burden, combined with the long course of drug treatment and an increasing incidence of antimicrobial resistance among M. tuberculosis isolates, necessitates novel drugs and drug targets for treatment of this deadly pathogen.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02661-18

Reference40 articles.

1. World Health Organization. 2018. Global tuberculosis report 2018. World Health Organization, Geneva, Switzerland.

2. Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe