Genetic Variation in Toll-Like Receptor 5 and Colonization with Flagellated Bacterial Vaginosis-Associated Bacteria

Author:

dela Cruz Erin J.123ORCID,Fiedler Tina L.3,Liu Congzhou3,Munch Matthew M.3,Kohler Christina M.3,Oot Antoinette R.3,Wallis Jacqueline M.3,Wang Junhui3,Frishman Anna3,Garcia Kristina3,Wiser Andrew3,Balkus Jennifer E.34,Srinivasan Sujatha3,Golob Jonathan L.35ORCID,Sycuro Laura K.67,Marrazzo Jeanne M.8,Hawn Thomas R.5,Fredricks David N.35ORCID

Affiliation:

1. Medical Scientist Training Program, School of Medicine, University of Washington, Seattle, Washington, USA

2. Molecular and Cellular Biology, School of Medicine, University of Washington, Seattle, Washington, USA

3. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

4. Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA

5. Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA

6. Department of Microbiology, Immunology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

7. Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

8. Division of Infectious Diseases, Department of Medicine, University of Alabama School of Medicine, Birmingham, Alabama, USA

Abstract

Bacterial vaginosis (BV) is a vaginal dysbiotic condition linked to negative gynecological and reproductive sequelae. Flagellated bacteria have been identified in women with BV, including Mobiluncus spp. and BV-associated bacterium-1 (BVAB1), an uncultivated, putatively flagellated species.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Human Genome Research Institute

HHS | NIH | National Institute of General Medical Sciences

American Society for Microbiology

Achievement Rewards for College Scientists Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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