Abstract
Coxiella burnetii was examined for superoxide anion (O2-) production and superoxide dismutase and catalase activities. The organism generated O2- at pH 4.5 but not at pH 7.4. The rickettsia displayed superoxide dismutase activity distinguishable from that of the host cell (L-929 mouse fibroblast). Catalase activity was maximal at pH 7.0 and diminished at pH 4.5. These enzymes may account, in part, for the ability of this obligate intracellular parasite to survive within phagocytes.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference38 articles.
1. Influence of catalase activity on resistance of coagulase-positive staphylococci to hydrogen peroxide;Amin V. M.;Appl. Microbiol.,1968
2. Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase;Babbor B. M.;J. Lab. Clin. Med.,1975
3. Baca 0. G. E. T. Akporlaye A. S. Aragon I. L. Martinez M. V. Robles and N. L. Warner. 1981. Fate of phase I and phase II Coxiella burnetii in several macro
4. phage-like tumor cell lines;Infect. Immun.,1983
5. Direct demonstration of superoxide anion production during the oxidation of reduced flavin and of its catalytic decomposition by erythrocuprein;Balok D.;Biochem. Biophys. Res. Commun.,1969
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