Comparison of Four Molecular In Vitro Diagnostic Assays for the Detection of SARS-CoV-2 in Nasopharyngeal Specimens

Author:

Zhen Wei1,Manji Ryhana1,Smith Elizabeth1,Berry Gregory J.12

Affiliation:

1. Infectious Disease Diagnostics, Northwell Health Laboratories, Lake Success, New York, USA

2. Department of Pathology and Laboratory Medicine, The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, New York, USA

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel human coronavirus that causes coronavirus disease 2019 (COVID-19), was first discovered in December 2019 as the cause of an outbreak of pneumonia in the city of Wuhan, Hubei province, China. The clinical presentation of COVID-19 is fairly nonspecific, and symptoms overlap those of other seasonal respiratory infections concurrently circulating in the population. Furthermore, it is estimated that up to 80% of infected individuals experience mild symptoms or are asymptomatic, confounding efforts to reliably diagnose COVID-19 empirically.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference18 articles.

1. WHO. 2020. Coronavirus disease (COVID-19) outbreak. World Health Organization. https://www.who.int/emergencies/diseases/novel-coronavirus-2019. Accessed 23 April 2020.

2. CDC. 2020. Locations with confirmed COVID-19 cases global map. Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/global-covid-19/index.html. Accessed 23 April 2020.

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4. Hosts and Sources of Endemic Human Coronaviruses

5. COVID-19: Zoonotic aspects

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