Structure of Parvovirus B19 Decorated by Fabs from a Human Antibody-Reference-Cited by-同舟云学术

Structure of Parvovirus B19 Decorated by Fabs from a Human Antibody

Published:2019-05 Issue:9 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sun Yingyuan¹,Klose Thomas¹,Liu Yue¹^ORCID,Modrow Susanne²,Rossmann Michael G.¹

Affiliation:

1. Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA

2. Institute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany

Abstract

Parvovirus B19 is a common human pathogen and a particular threat to children, pregnant women, and patients with sickle cell disease or AIDS. Currently, neutralizing antibody is the most efficient treatment for acute B19 infections. Research on the antigenic properties of B19 will guide the usage of these antibodies and facilitate vaccine development. We have determined and report here the high-resolution structure of B19 virus-like particles (VLPs) complexed with the Fab of a human neutralizing antibody. The structure shows a quaternary structure epitope formed by three VP2 proteins and provides details on host recognition of human B19 virus.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01732-18

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