Deep Gene Sequence Cluster Analyses of Multi-Virus-Infected Mucosal Tissue Reveal Enhanced Transmission of Acute HIV-1-Reference-Cited by-同舟云学术

Deep Gene Sequence Cluster Analyses of Multi-Virus-Infected Mucosal Tissue Reveal Enhanced Transmission of Acute HIV-1

Published:2021-01-13 Issue:3 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Klein Katja¹,Nankya Immaculate²,Nickel Gabrielle³,Ratcliff Annette N.³,Meadows Adam A. J.¹,Hathaway Nicholas⁴,Bailey Jeffrey A.⁵,Stieh Daniel J.⁶,Cheeseman Hannah M.⁷,Carias Ann M.⁸,Lobritz Michael A.³,Mann Jamie F. S.¹,Gao Yong¹³,Hope Thomas J.⁸^ORCID,Shattock Robin J.⁶⁷,Arts Eric J.¹²³^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada

2. Joint Clinical Research Centre, Kampala, Uganda

3. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

4. Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA

5. Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA

6. Department of Cellular and Molecular Medicine, St. George’s, University of London, London, United Kingdom

7. Department of Medicine, Imperial College London, London, United Kingdom

8. Department of Cellular and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Abstract

During heterosexual HIV-1 transmission, a genetic bottleneck occurs in the newly infected individual as the virus passes from the mucosa, leading to systemic infection with a single transmitted HIV-1 clone in the recipient. This bottleneck in the recipient has just been described, and the mechanisms involved in this selection process have not been elucidated.

Funder

Horizon 2020

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01737-20

Reference54 articles.

1. Estimating per-act HIV transmission risk

2. Sustained High HIV Incidence in Young Women in Southern Africa: Social, Behavioral, and Structural Factors and Emerging Intervention Approaches

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