Micafungin at Physiological Serum Concentrations Shows Antifungal Activity against Candida albicans and Candida parapsilosis Biofilms

Abstract

ABSTRACTWe assessed thein vitroactivity of micafungin against preformedCandidabiofilms by measuring the concentration of drug causing the most fungal damage and inhibition of regrowth. We studied 37 biofilm-producingCandidaspp. strains from blood cultures. We showed that micafungin was active against planktonic and sessile forms ofCandida albicansstrains and moderately active againstCandida parapsilosissessile cells. Concentrations of micafungin above 2 μg/ml were sufficiently high to inactivate regrowth ofCandidasessile cells.